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When tested in a mouse model, rosmarinic acid(RA), a polyphenol found in Lamiaceae herbs, showed that it inhibits the accumulation of phosphorylated tau protein and improves spatial memory ( Curcumin, a primary component of the Indian spice turmeric, has been shown to have an inhibitory effect on tau aggregation with a reduction in tau oligomer ( Tau-protein clearance is increased by treatment with vaccines or antibodies, and multiple clinical trials for tauopathies are currently testing this approach ( A multicenter phase-1b/2a study is being conducted to evaluate the safety and immunogenicity of this vaccine in Alzheimers disease (AD) patients(NCT04445831).BIIB092 is a humanized monoclonal antibody developed against an N-terminal fragment of tau (extracellular tau) secreted from familiar AD-patient-derived pluripotent stem cells

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