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DSIP does not have comparable long-term safety evidence, and the FDA has raised concerns about insufficient safety data and quality-control issues involving compounded DSIP products

Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

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ISBN 978-1-135-92841-4