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Future interventions that selectively modulate neutrophil activation, ROS generation, or NET formationsuch as PAD4 inhibitors, ROS scavengers, DNase-based therapies, or blockade of neutrophilplatelet interactionshold promise to shift PCOS management from symptomatic hormone modulation toward precision immuno-metabolic therapy

Campagna MC, Taketa T, Correa AM, Sudo K, Blum MA, Wadhwa R, Komaki R, Lee JH, Bhutani MS, Weston B, Liao ZX, Rice DC , Swisher S, Hofstetter WL, Ajani JA

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Am J Kidney Dis 26(5):757764