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Blood-brain barrier The concept of the BBB can be traced back to the finding by Humphrey Ridley in 1695 [1, 2]

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(2017) observed increased gut permeability in a unique assay which assessed the rise in portal vein trimethylamine (TMA, a metabolite produced by the gut microbiota) concentrations following intracolonic TMA infusion in 2426-week old SHRs relative to age-matched WKY rats [93]

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