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Studies have shown that DAP and reuterin can inhibit the heterodimerization of HIF-2 with the aryl hydrocarbon receptor nuclear translocator, thereby downregulating the expression of intestinal iron absorption-related genes and subsequently limiting iron uptake (51)

The influence of the gut microbiome on host metabolism through the regulation of gut hormone release

Studies (75, 76) have shown that NOR can inhibit the destruction of bone and cartilage in AIA rats by reducing the expression of RANKL, IL-6, PGE2 and MMP-13 through the p38/ERK/AKT/AP-1 pathway

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