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From the genetics angle, there are some pediatric, congenital causes of 5-oxoprolinuria which not surprisingly involved defects in enzymes of the gamma-glutamyl cycle (in particular, mutations in glutathione synthetase and 5-oxoprolinase have been identified in these patients).

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Unlike traditional brightening or antioxidant supplements, AOX Glutathione works at the cellular level, directly combating oxidative stress and dull skin to reveal a healthier, more radiant complexion over time

8:e1492

[DOI] [PubMed] [Google Scholar] 68.Sabharwal S