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However, further clinical trials are necessary to evaluate the safety and efficacy of TKI as adjunctive therapies in TB treatment, with a focus on understanding how TKI might be safely integrated into clinical practice

Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, et al

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[10] The key is protecting glutathione through the digestive process and enhancing cellular uptake

Although the maximum plasma concentration is lower when compound 2 is administered PO (0.77 M) instead of IP (4.8 M), it is still 4.3-fold higher than LD 50 for ex vivo NTS determined in the commonly used 72 h assay, also indicating that TGR inhibitor 2 is orally bioavailable and the initial prediction of oral bioavailability based on the Lipinski et al