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Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)

doi: 10.1021/acs.chemrev.0c00199 225 LeeY.RobbinsN.CowenL

Zofran is a medicine that prevents nausea by blocking signals to the brain and digestive tract that cause nausea and vomiting

Oxidative StressInduced Metabolic Syndrome Oxidative stress serves as the central pathological nexus in metabolic syndrome, which is characterized by abdominal obesity, insulin resistance, inflammation, high blood pressure, and blood lipid disorders [117]