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therefore, studies by Miyakawa et al

The convergence of all of these proteins on mitochondrial dynamics uncovers a common function in the mitochondrial stress response that might provide a potential physiological basis for the pathology of PD (Norris et al., 2015

Clinically, oral or intravenous riboflavin remains first-line treatment

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However, the direct use of HGF or any other protein neurotrophic factor as a therapeutic agent has two serious limitations: 1) large size and hydrophilic character, which preclude BBB permeability