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Outside the context of NDDs, CRISPRa has been used to target the KCNA1 voltage-gated potassium channel to rescue seizure frequency and cognitive dysfunctions in a mouse model of epilepsy [79]

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This theoretical framework, enriched with the Italian Territorialist School knowledge, was tested through the development of a methodology designed to delineate the CRFS using the territoriality concepts as proposed by geographic scholarship also in relation to food systems