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Intracellular GSH levels regulate lymphocyte proliferation, T-cell activation, NK cell cytotoxicity, and macrophage function [7][8]

As a powerful antioxidant, glutathione neutralizes free radicals, thereby preventing them from causing cellular damage

doi:10.1128/AAC.00773-07

Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression