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Mary Stevenson, associate professor of dermatology at NYU Langone Health, previously told USA TODAY

At low doses (125 g/kg), metformin activates AMPK, enhancing endothelial nitric oxide synthase (eNOS) activity, improving vascular function, and reducing myocardial injury (Zhou et al., 2001)

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This reduces the elasticity and firmness of the skin, leading to the formation of wrinkles and loss of facial definition

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