Risk-benefit analysis should consider the severity and impact of the condition being treated, failure or limitations of conventional therapies, individual patient risk factors particularly for malignancy, and patient preferences regarding experimental treatments
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(154) highlighted the metabolic reprogramming in CRC, which includes the overexpression of enzymes such as ARG1, PRMTs, and DDAHs, in addition to NOS2
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This suggests involvement in neovascularization processes