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Conformers of AITC were evaluated based on their binding affinities and acceptable RMSD values ( 2 )
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Science 358 , 522528 (2017)
This is likely due to structural differences: ipamorelin Aib/D-2-Nal backbone produces a different binding mode at GHS-R1a that may favor specific downstream signaling pathways (biased agonism) compared to the His/D-Trp backbone of GHRP-6
