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UBX0101, a p53/MDM2 interaction inhibitor, improves osteoarthritis by eliminating senescent synovial cells in the knee joint

96 Macrophages Among the non-parenchymal cells involved in liver regeneration, the role of macrophages has been well highlighted in clinical patients and mouse models

The recommendations could pave the way for the FDA to reclassify the compounds so they can be obtained from specialized pharmacies in the U.S

Therefore, treatment should follow assessment and structured dosing

Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11