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Nature 526, 666671

Cellular stress and especially DNA lesions trigger the DNA damage sensor protein, PARP1, which consumes NAD + for loosening up chromatin at specific loci to enhance DNA repair and for PARylation, a process by which PAR chains are generated to serve as a docking platform for the recruitment of other DNA repair proteins, with high biochemical complexity

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Small molecules and peptides bearing electrophilic moieties have previously been reported as GSTO1 inhibitors 20,21,22,23,24

10.1038/sigtrans.2017.23 63 LiuS.JinX.GeY.DongJ.LiuX.PeiX.et al (2025)