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Vigorous shaking can damage the delicate peptide chains through mechanical stress, a process called shearing

A frequent side effect of renal failure, parathyroid hormone overproduction, can also cause the release of calcium from your bones

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39 De GiorgioR.GuerriniS.BarbaraG.StanghelliniV.De PontiF.CorinaldesiR.et al (2004)

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