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This was evident from the significant drop in TER, increased IL-8 secretion along with enhanced cytotoxic reactiveness in TC culture models compared to the DC culture model (Fig

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Br J Med Med Res

The results consistently indicated that smokers achieved a lower plasma concentration of the drug compared to non-smokers at the same dose, or a lower concentration/dose (C/D) ratio in smokers [28, 43, 61, 70]