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Cystinosin deficiency leads to impaired lysosomal clearance and disrupted endolysosomal trafficking, which in turn contributes to defective autophagy and altered proteostasis [144, 146, 147]

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4 Metabolic interactions in the hepatocellular carcinoma tumor microenvironment 4.1 Metabolic crosstalk between hepatic stellate cells and hepatocellular carcinoma cells Cancer cells maintain an alkaline intracellular environment by undergoing aerobic glycolysis, which generates a large amount of protons that are transported to the extracellular space through upregulation of H+ transport proteins

siRNA Whitening Technology: The unique siRNA (small interfering RNA) complex directly targets melanogenesis (melanin production pathways), enhancing the whitening effect while maintaining skin health and balance

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