Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mgi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga J-J, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, et al
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Metabolic findings in rodents have a long history of not translating cleanly, so the fat-loss story should be read as promising preclinical data, not an established human outcome
From there, it may interact with multiple signaling cascades involved in cellular communication and regulation
Cells were lysed in 100 L ice cold 8 M Urea/50 mM Tris HCl lysis buffer (Fisher Scientific) with 1:100 of Halt Cocktail Inhibitor, EDTA-free (100X) (Thermo Scientific)