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Researchers gave creatine to patients with Alzheimer's disease and observed an 11% increase in brain creatine levels along with moderate improvements in working memory and executive function

In SV40-MES 13 cells, HMGB1 (high-mobility group box-1) has been recognized as a valuable factor of ferroptosis based on the Nrf2/HO-1 signaling pathway, proposing that HMGB1 is a new target for the treatment of DN [157]

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NICE Technology Appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) for use in adults with obesity or overweight with at least one weight-related comorbidity, when used alongside a reduced-calorie diet and increased physical activity

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