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Here's an angle that often gets overlooked: copper is a required cofactor for tyrosinase , the enzyme that produces melanin

It acts as a key regulator for many bodily processes

Eur J Pharmacol 570:212221 Veljaca, M, Krnic, Z and Brajsa, K (2002) The development of PL 14736 for treatment of inflammatory bowel disease

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Emergency department visits, including visits that result in a hospital admission, range from 1,154 per 1,000 beneficiaries annually in Nebraska to 1,811 per 1,000 beneficiaries annually in West Virginia, and the percentage of hospital stays followed by hospital readmission within 30 days ranges from 16% in Hawaii to 25.8% in Nevada