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Vitamin B 12 deficiency, like folate deficiency, may lead to decreased synthesis of methionine and S-adenosylmethionine (SAM), thereby adversely affecting methylation reactions

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Furthermore, another study focusing on GC revealed that MACC1 enhances MET expression and stimulates the downstream AKT/mTOR pathway, which consequently leads to increased PD-L1 expression levels in GC [132]