Discussion Here, we established a closed loop between supramolecular transformation and genetic response, enabling influxefflux cycles of synthetic nanostructures within living cells, during which intracellular redox and energy homeostasis were restored
Every milliliter of solution contains 2.5 mg of peptide
Of course, we can not only stay in the perspective of mitophagy, we also need to consider a variety of factors, after all, the microenvironment of cardiomyocyte survival is composed of a variety of different substances, for example, endothelial cells and blood cells including platelets may also play a role in mitophagy affecting cardiomyocytes
However, sterility of the product matters significantly in this context
We illustrate significance in the figures of this manuscript with the following conventions: p 0.05 is denoted with *, p 0.01 is denoted with ** and p 0.001 is denoted with ***