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As previously shown 26 , recombinant AT-1002, the active domain of Vibrio choleraes zonula occludens toxin (ZOT, zonulin) on average tended to decrease the transepithelial electrical resistance (TEER) in Caco-2 cell monolayers, indicating the permeability of epithelial cell monolayers (Fig

FDA approval Phase 1, 2 and 3 clinical trials require companies to perform extensive clinical studies to determine drug safety and efficacy