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A single puff of vape aerosol contains nicotine (in most products), propylene glycol and glycerin (solvents), flavoring chemicals, carbonyls (formed by heating), and metals like nickel, tin, and lead from device components

Tobacco smoke contains numerous carcinogens capable of inducing DNA damage, oxidative stress, and inflammatory responses, all of which can promote tumor initiation and progression

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Notably, human serum albumin functions as a molecular chaperone by binding to exposed hydrophobic regions 74