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AMP-activated protein kinase (AMPK) is a central regulator of lipid homeostasis and mediates suppression of lipogenic gene expression, such as acetyl-coenzyme A-carboxylase (ACC) and fatty acid synthase (FAS) through inhibition of sterol regulatory element binding protein-1c (SREBP1-c) and carbohydrate response-element binding protein (ChREBP) (3335)

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