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The cumulative effect of smoking a pack of cigarettes daily typically results in greater total exposure to harmful substances than occasional joint use

Here we review the immunosuppressive effects of cigarette smoke and the mechanisms by which smoking affects host innate immunity including structural and functional changes in the respiratory ciliary epithelium, lung surfactant protein, and immune cells such as alveolar macrophages, neutrophils, lymphocytes and natural killer (NK) cells

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