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The main mechanism is thought to be destructive thyroiditis caused by cytotoxic T-cells, particularly when the PD-1/PD-L1 pathway is blocked

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We randomly selected sections of at least 6 fields of each sample for the quantification of each positive signal for histopathological changes and fibrosis, which is indicated by the red or blue area based on the amount of collagen by Image-Pro Plus 6.0 software (Version X

Braun et al

In fact, over half of all acute liver failure cases in the United States are due to acetaminophen overdose (2)