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As CNS GSH concentrations are thought to be reduced in PD, a relatively large voxel size was selected in order to maximize signal to noise

This might be due to the restricted quantity of BER that can be captured in the phospholipid layer of anionic liposomes besides, the hydrophilic drug is typically encapsulated with low efficiency due to the presence of a large volume of external aqueous hydration medium, So, very little content of hydrophilic drug can be entrapped within the aqueous core of the liposome [75]

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