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Simultaneous activation of tissue repair, anti-inflammatory, immune, and regenerative pathways addresses healing from every angle for optimal outcomes

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doi: 10.1071/FP19220 10 AlsafranM.UsmanK.AhmedB.RizwanM.SaleemM

The release of lipid peroxidation products and oxidative stress signals during ferroptosis activates inflammatory pathways in synovial cells, such as the NF-B and MAPK pathways, resulting in the release of additional inflammatory factors and creating a vicious cycle (Kumar et al., 2019