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Because AOD-9604 and the incretins act through non-overlapping mechanisms (adipose lipolysis versus incretin signaling), some research protocols examine growth-hormone-fragment and incretin approaches in combination or in parallel arms which is why AOD-9604 appears as a "frequently paired" compound alongside semaglutide and tirzepatide

HGH has several known metabolic functions, including induction of insulin-like growth factor-1 (IGF-1) and lipid and carbohydrate metabolism

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