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[35] observed that kava extract or a mixture of the 6 six major kavalactones present in the extract inhibited the expression of CYP2C9, CYP2C19, CYP2D6, CYP3A4 in human hepatic microsomes

Antioxid Redox Signal 2017, 26 (13), 718742

Its antioxidant properties further support barrier function by neutralizing free radicals, as noted in Pickart et al

Concurrently, sustained IFN- feedback further augments local inflammation and T-cell recruitment, potentially through the activation of antigen-presenting cells such as DCs and macrophages [35]