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Whereas previous studies also have found that diabetic patients have deficient cellular levels of GSH (35), the present data go further to demonstrate that the GSH deficiency seems to be attributed to a markedly lower synthetic rate of GSH and is associated with increased oxidant stress and elevated plasma markers of oxidant damage
Furthermore, the acyl-CoA synthetase long chain family member 4 (ACSL4)-mediated ferroptosis showed a tumor-promoting role in the progression of hepatocellular carcinoma (HCC) from liver injury and a tumor-suppressing role in HCC treatment (3)
An unrelated monoclonal antibody neutralizes human immunodeficiency virus type 1 by binding to an artificial epitope engineered in a functionally neutral region of the viral envelope glycoproteins
Newsholme P, Procopio J, Lima MMR et al (2003) Glutamine and glutamatetheir central role in cell metabolism and function
