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Group III received the standard drug leflunomide at a dose of 10 mg/kg orally from days 22 to 42 followed by CFA administration

Peptide therapies work by signaling natural processes in the body related to tissue repair, metabolism, inflammation regulation, and growth hormone pathways

In the liver, the reactive metabolite NAPQI is intercepted by glutathione before it can react with liver proteins

Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

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