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2 Methodology We conducted a structured literature search using PubMed, Web of Science, and Scopus databases for studies published between January 2010 and March 2025

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1) Cell type- and nephron segment-specific susceptibility: The kidney is a highly heterogeneous organ, with distinct nephron segments [PT, distal tubule (DT), collecting duct (CD)] and cell types (podocytes, mesangial cells, interstitial fibroblasts, and endothelial cells) exhibiting divergent ferroptosis susceptibility