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NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services

Shelf Life Summary Powder (fridge): 1224 months Powder (freezer): 24+ years Reconstituted liquid (fridge): 38 weeks Reconstituted liquid (frozen aliquots): Several months with cryoprotectant Dont Do This Dont use tap or boiled water

Storage: Keep in a cool, dry place away from direct sunlight

Timing consistency during titration is critical

Step 3: Inject with Minimal Discomfort To make the injection as painless as possible, start by cleaning the chosen spot with an alcohol wipe and letting it air-dry completely