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Fawcett, D

Previous studies have shown that oncogenic RAS activation significantly augmented the activities of NOXs, which increase cellular ROS levels, leading to redox dysregulation and aberrant metabolic alterations 10,11,12,13

CHAC2 expression is also closely linked to several genetic mutations prevalent in breast cancer, most commonly TP53, as well as CDH1, BIRC6, DYNC2H1 and UTRN ( Thus, like CHAC1, CHAC2 represents an intriguing and complex target for further cancer research

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