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SLC Transporters GLUT9 ( SLC2A9 ) GLUT9 encoded by SLC2A9 gene is widely present in the proximal tubule in human kidney ( SLC2A9 gene

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Drugs 18 , 639 (2020)

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Evidence showed that excess intracellular hydrogen peroxide regulates the expression of various NF-B component proteins, and the alterations in the composition or quantity of the NF-B dimer can change down-stream target gene expression, and conduce to the upregulation of pro-inflammatory genes and a pro-apoptotic environment ( In summary, we investigated the role of GPX1 in protecting SGNs against oxidative stress by upregulating or inhibiting the expression of GPX1 in SGNs via the GPX1 mimic ebselen or the gpx1 knockout mouse model, and further determined the mechanistic details behind the neuroprotective effect of GPX1 in SGNs against peroxynitrite injury