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ACS Chem Neurosci 12:33353346 Hofmann C, Pizzagalli F, Boetsch C, Alberati D, Ereshefsky L, Jhee S, Patat A, Boutouyrie-Dumont B, Martin-Facklam M (2016) Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers

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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

Some research framings use a 5-days-on / 2-off pattern to build in a weekly break