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Therefore, testicular increases in IGF1 could mediate functional differentiation of testosterone-producing LCs in rhGH rats, and the increased circulating testosterone in rhGH rats may be due to the increased LH response in LCs by the testicular IGF1

If you move from 0.5% to 1% to 2% in quick succession, you can't know which concentration was responsible for any observed improvements

Toxicol Appl Pharmacol (2015) 289(2):21322

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