In some embodiments, the formulations or composition described herein have a pH and osmolarity as described herein, and have a concentration of active pharmaceutical ingredient between about 0.1-about 70 mg/mL, between about 1 mg-about 70 mg/mL, between about 1 mg-about 50 mg/mL, between about 1 mg/mL and about 20 mg/mL, between about 1 mg/mL to about 10 mg/mL, between about 1 mg/mL to about 5 mg/mL, or between about 0.5 mg/mL to about 5 mg/mL of the active agent by volume of the formulation or composition
Arif Ekici as well as Uwe Appelt and Markus Mroz from the University Hospital Erlangen core units Next Generation Sequencing and Cell Sorting and Immunomonitoring, respectively, for their technical support, and the personnel of the Franz-Penzoldt Preclincal Experimental Animal Center for their professional mouse care
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By encapsulating drug molecules in nanoparticles, nanoparticle drug delivery systems exhibit the advantage of improved drug loading, less exposure of the drug molecule to metabolic enzymes and drug efflux pumps, longer blood circulation, and facilitation of drug passage through the cell membrane via transcytosis instead of passive diffusion
