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doi:10.1371/journal.pone.0162590.g011 Diclofenac, L-NAME, L-Arginine and BPC 157 in Short-Bowel Rats PLOS ONE | DOI:10.1371/journal.pone.0162590 September 14, 2016 15 / 18 be part of a feedback mechanism that regulates egr-1-mediated gene transcription, cytokine and growth factor generation, and early extracellular matrix (collagen) and blood vessels formation [2629]

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Concurrently, this process produces ROS as a byproduct of the respiratory chain (Fig