While these agents often spare normal proliferating tissues, they introduce new toxicity patternssuch as dermatologic reactions, QT prolongation, diarrhea, and hepatotoxicityoften linked to the pathways they target in normal tissues
doi: 10.1038/s41419-017-0105-5 55 JonassenJ
In the body of the average adult male, the human liver can metabolize around 1 drink of alcohol per hour
all statistical analyses were conducted to calculate the weighted mean difference (WMD) for continuous data and odds ratio (OR) for dichotomous variables, together with the corresponding 95% CIs
The experimental data is listed in table 11.Table 11 The example data of preparation of L-carnitine from L-3-cyano-2-hydroxypropyl trimethylammonium having different optical purity Example 1 Establish the detecting method of the optical purity of epichlorohydrin with gas chromatography Example 2 Detection of the content of the D-isomer of the intermediate (L-3-cyano -2 - hydroxypropyl trimethyl ammonium) Example 3 Preparation of L-carnitine started from S-epichlorohydrin having different optical purity Example 4 Preparation of L-carnitine from L-3-chloro-2-hydroxypropyl trimethylammonium Example 5 Preparation of L-carnitine from L-3-cyano-2-hydroxypropyl trimethylammonium Claims (8) A Preparation Method of high-Purity L-carnitine, characterized in that to prepare L-carnitine with a purity being above 97%, wherein the content of D-carnitine is below 2%, by detecting and controlling the content of chiral material and chiral intermediate during the whole synthetic process which is started from S-epichlorohydrin, wherein the method include the following steps:(1)Detect the content of optical isomers of S-epichlorohydrin with GC and chiral column, and control the content of laevoisomer of S-epichlorohydrin within the range of 0% -12% W/W;(2)Detect the specific rotation of the intermediate L-3-chloro-2-hydroxypropyl trimethylamine during the synthetic process with a polarimeter, and control the value within the range of -26.0 -29.4;(3)Detect the optical purity of L-3-cyan-2-hydroxypropyl trimethylamine of the intermediate mixture and the content of its dextroisomer with a chiral derivatization reagent, and control the content of the dextroisomer within the range of 03.6%W/W;wherein the said chiral derivatization reagent is the optically pure D- or L-compound of formula (II):wherein, the carbon atom marked with an asterisk is the chiral carbon atom
