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The difference between the groups increased when evaluated at d 56 (28 d following last dose) at which point the mean improvement in the ARA 290 had increased to 4.2, and the placebo group diminished to 0.74 points

When vitamin B12 is deficient, the growth and development of cells and tissues in the body will be inhibited

Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species

Fibroblasts play an important role in turnover of extracellular matrix