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doi: 10.1016/S0940-2993(99)80074-8

Previous research suggests DSIP can influence biosynthetic processes in the brain, reduce stress protein factors, and potentially affect glutamate and GABA receptors in regions like the cortex, thalamus, and hippocampus

166 Third, GSK3 is activated in the AD brain, and the hyperphosphorylation of tau protein in AD patients is mediated by GSK-3