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Human studies provide topical and wound-care context [1] [2] [3] [4] [5] , while an animal wound model provides local-administration context [6]

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Studies show FOXO4-DRI treatment reduces senescent cell markers including p16, p21, and senescence-associated -galactosidase activity by over 50% in expanded human chondrocytes at population doubling level 9 (PDL9), the stage typically used for clinical implantation