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Titration step values follow the REDEFINE Phase 3 protocol structure as reported by Novo Nordisk and the NEJM publications

Growth Hormone Receptor Upregulation : It may increase growth hormone receptors at the site of injury, enhancing the effects of growth hormone, which plays a critical role in tissue repair and regeneration 3 4

A probability plot showed that similar to the data from the IMPACT 2 trial, this difference was driven by the 20% of placebo patients who had progressive radiographic damage (Figure 7-13)

The diversity of symptoms and clinical heterogeneity of SCA3 patients reflects the pattern of central nervous system (CNS) cell degeneration