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Vitamin B1 (thiamine) functions as a coenzyme with the transketolase enzyme in the pentose phosphate pathway of glycolysis

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In addition, decreased soluble UCHL1 protein levels was detected in the brains of postmortem AD patients and APP/PS1 mouse models (Gong et al., 2006), and soluble UCHL1 is inversely proportional to the number of NFTs in AD brains (Gong et al., 2006)

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