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Although breast cancer cell lines exhibit increased resilience to physiologically relevant shear stress compared to normal epithelial cells [223], lamin A/C knockdown exacerbates shear stress-mediated tumor cell death [223], suggesting that elevated lamin A/C levels could aid breast CTCs in withstanding shear forces in the circulation

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Peltroche-Llacsahuanga H, Goyard S, dEnfert C, Prill SK, Ernst JF (2006) Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans

After multiple iterations and improvements, several analogs have progressed to clinical trials